Recurrent loss of the FHIT gene and its impact on lymphatic metastasis in early oral squamous cell carcinoma

YH Joo, SW Park, SH Jung, YS Lee, IC Nam… - Acta oto …, 2013 - Taylor & Francis
Conclusion: Our findings show that copy number loss of FHIT is associated with lymph node
metastasis (LNM) and suggest that the down-regulation of Fhit indicates poor prognosis in
early oral squamous cell carcinoma (OSCC). Objectives: The purpose of this study was to
identify alterations in genetic markers related to LNM in early OSCC. Methods: Genome-
wide copy number alterations were analyzed in 14 early OSCCs with (n= 7) or without (n= 7)
cervical LNM using 180K array-comparative genomic hybridization. To explore the …
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